Hybrid Approaches for Structural Prediction

This is a cost-effective approach for determining the protein structure. The computational prediction methods, such as initiating fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied in recent times to expand our understanding on protein structures. However, speculating the structures of proteins remains a confront, with congestions from both force field and conformational search.  Hybrid approach is a way to overcome these disadvantages, by including the limited experimental measurements, reliable structures that can be computed, and unlikely predictions are eliminated. The current researches are showing great interest in this method of approach.