Analytical Techniques

Biomolecules are too small to view even by the advanced microscopes. Structure probing biochemical techniques determine these biomolecular structures in vast numbers of the same identical molecules at once. Scientists use them to study the "native states" of biomolecules. Few of the best methods determining the structures include X-ray crystallography, Cryo-Electron Microscopy and Nuclear Magnetic Resonance.

  • Mass spectrometry
  • Macromolecular crystallography Proteolysis
  • Nuclear magnetic resonance spectroscopy of proteins (NMR) 
  • Electron paramagnetic resonance (EPR)
  • Cryo-electron microscopy (cryo-EM)
  • Multiangle light scattering
  • Small angle scattering
  • Ultrafast laser spectroscopy
  • Dual-polarization interferometry and circular dichroism